Rodríguez-Manzaneque, Juan Carlos

Proteases and Extracellular Matrix

Rodríguez-Manzaneque, Juan Carlos
Rodríguez-Manzaneque, Juan Carlos
Proteases and Extracellular Matrix

GENYO. Center for Genomics and Oncological Research, Granada

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angiogenesis, extracellular matrix, immune response, proteolysis, vasculature
Brief description of the research:

The understanding of tumor angiogenesis, basic component for the growth of solid tumors and for the development of metastasis, has suffered enormous advances during the last decades. In fact this research contributed very significantly to address the current challenges to properly attack tumor heterogeneity. Our efforts have been focused to unveil the contribution of extracellular proteases according to their modulatory capacity of the extracellular framework, quite far from the simplistic view of a scaffold and maintenance service. Together with the functional characterization of every existing extracellular protease, it is required to envision such proteolytic activity in a specific scenario, highlighting the relevance of hypoxic-sensitive pathways. The detailed characterization of the tumor microenvironment and its remodelling by proteolysis, together with the extracellular and cellular components of the vascular niche, are a current priority, with special relevance for the understanding of mechanisms of drug resistance that certain tumors develop.

5 selected publications:
  1. Rodríguez-Baena FJ, Redondo-García S, Peris-Torres C, Martino-Echarri E, Fernández-Rodríguez R, Plaza-Calonge MDC, Anderson P, Rodríguez-Manzaneque JC. ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response. Sci Rep. 2018 Aug 30;8(1):13103.

  2. Fernández-Rodríguez R, Rodríguez-Baena FJ, Martino-Echarri E, Peris-Torres C, Del Carmen Plaza-Calonge M, Rodríguez-Manzaneque JC. Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis. Oncotarget. 2016 Jun 7;7(23):34507-19.

  3. Rodríguez-Manzaneque JC, Fernández-Rodríguez R, Rodríguez-Baena FJ, Iruela-Arispe ML. ADAMTS proteases in vascular biology. Matrix Biol. 2015 May-Jul;44-46:38-45.

  4. Casal C, Torres-Collado AX, Plaza-Calonge Mdel C, Martino-Echarri E, Ramón Y Cajal S, Rojo F, Griffioen AW, Rodríguez-Manzaneque JC. ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells. Cancer Res. 2010 Jun 1;70(11):4676-86.

  5. Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12485-90.