Ramón y Cajal, Santiago

Vall d'Hebron Institute de Recerca (VHIR)

Vall d'Hebron Institute de Recerca (VHIR)

Department of Pathology Vall d'Hebron University Hospital

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Phone number

+34 932 746 824/ 934 894 569

URL

Department of Pathology VHIR

Twitter

@hypoxia

Keywords

Pathology, Cancer, Tumor Heterogeneity, Clonal Cooperation, Cellular Stress

Brief description of the research:

Combing pathology and molecular biology, the aim of our group is to unravel the molecular mechanisms in cancer progression and chemotherapeutic drug resistance. Our research focuses on:

Cellular Stress related to Cancer
- Validation and characterization of novel Mnk1/2 inhibitors.
- Characterization of ITGB3 as a potential therapeutic target.
Intra tumor heterogeneity and clonal cooperation
Taking advantage of having the expertise and availability of primary tumors in the Pathology department and the molecular and cell biological expertise in the research group, we are in a privileged position to study the different aspects of tumor biology at the pathological and molecular level at the same time.

5 selected publications:

Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N. Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene. 2018 May;37(19):2490-2501.
Sesé M, Fuentes P, Esteve-Codina A, Béjar E, McGrail K, Thomas G, Aasen T, Ramón Y Cajal S. Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo. Oncotarget. 2017 Dec 12;8(70):114856-114876.
Ramón Y Cajal S, Capdevila C, Hernandez-Losa J, De Mattos-Arruda L, Ghosh A, Lorent J, Larsson O, Aasen T, Postovit LM, Topisirovic I. Cancer as an ecomolecular disease and a neoplastic consortium. Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):484-499.
Martínez-Sáez E, Peg V, Ortega-Aznar A, Martínez-Ricarte F, Camacho J, Hernández-Losa J, Ferreres Piñas JC, Ramón Y Cajal S. peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas. Cancer Med. 2016 Sep;5(9):2501-12.
Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS One. 2015 Apr 29;10(4):e0123352.