Pascual, Alberto

Mechanisms of neuronal maintenance

Pascual, Alberto
Pascual, Alberto
Mechanisms of neuronal maintenance

Instituto de Biomedicina de Sevilla (IBiS)

Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla

Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.

Phone number
Hypoxia, microglia, endothelial cells, Alzheimer’s disease, angiogenesis
Brief description of the research:

We are investigating the effect of hypoxia on the progression of Alzheimer’s disease. We are particularly interested in the role of the HIF/PHD pathway in microglia, the brain innate immune cells, and endothelial cells. We use genetically modified mice combined with histology, behaviour, biochemistry, and molecular biology.

5 selected publications:
  1. Serrano-Pozo, A., Sánchez-García, M.A., Heras-Garvín, A., March-Díaz, R., Navarro, V., Vizuete, M., López-Barneo, J., Vitorica, J., Pascual, A. Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo. PLoS ONE (2017) 12(1):e0170345. (*) Corresponding authors

  2. Ortega-de San Luis, C., Pascual, A. Simultaneous detection of both GDNF and GFRalpha1 expression patterns in the mouse central nervous system. Frontiers in Neuroanatomy (2016) 10:1-24.

  3. Gao, L., Hidalgo-Figueroa, M., Escudero, L.M., Lopez-Barneo, J. and Pascual, A. (2013) Age-mediated transcriptomic changes in adult mouse substantia nigra. PLoS ONE. 8:e62456(1-12). (*) Corresponding authors

  4. Hidalgo-Figueroa, M., Bonilla, S., Gutiérrez, F., Pascual, A., López-Barneo, J. (2012) GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway. The Journal of Neuroscience. 32:864-872. (*) Corresponding authors

  5. Romero-Ruiz A, Bautista L, Navarro V, Heras-Garvin A, March-Diaz R, Castellano A, Gomez-Diaz R, Castro MJ, Berra E, Lopez-Barneo J, Pascual A. (2012) Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation in acute hypoxia. J Biol Chem. 287: 9651-9658. (*) Corresponding authors