Pardal, Ricardo

Physiopathology of neural stem cells

Pardal, Ricardo
Pardal, Ricardo
Physiopathology of neural stem cells

Instituto de Biomedicina de Sevilla (IBiS)

Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla

Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.

Carotid body germinal niche, neurogenesis and angiogenesis, Neural crest-derived stem cells, hypoxia, neuroblastoma
Brief description of the research:

Our group studies the biology of progenitor/stem cells in the adult nervous system. These cells reside in specific niches, from where they participate in the development, maintenance and repair of the neural tissue. The cellular and molecular contacts established within the niche, between the stem cells and the rest of the niche components, are essential for the normal functioning of neural stem cells. A disruption of these niche crosstalks could lead to disease conditions, due to a lack of regenerative capacity or to hyperproliferation within the niche. We have two models in which to study these niche interactions: 1.- the physiology of an adult peripheral neurogenic niche, the carotid body; 2.- the pathology of a neural crest-derived tumor, the neuroblastoma. Our detailed studies on the physiological and pathological behaviour of neural stem cells, including their responses to environmental hypoxia, might contribute to the understanding of the mechanisms underlying tumorigenic growth within the nervous system.

5 selected publications:
  1. Sobrino V, González-Rodríguez P, Annese V, López-Barneo J, Pardal R. Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia. EMBO Rep. 2018 Mar;19(3). pii: e44598.

  2. Linares-Clemente P, Aguilar-Morante D, Rodríguez-Prieto I, Ramírez G, de Torres C, Santamaría V, Pascual-Vaca D, Colmenero-Repiso A, Vega FM, Mora J, Cabello R, Márquez C, Rivas E, Pardal R. Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma. Oncotarget. 2017 Sep 21;8(52):89775-89792.

  3. Annese V, Navarro-Guerrero E, Rodríguez-Prieto I, Pardal R. Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body. Cell Rep. 2017 Apr 18;19(3):471-478.

  4. Navarro-Guerrero E, Platero-Luengo A, Linares-Clemente P, Cases I, López-Barneo J, Pardal R. Gene Expression Profiling Supports the Neural Crest Origin of Adult Rodent Carotid Body Stem Cells and Identifies CD10 as a Marker for Mesectoderm-Committed Progenitors. Stem Cells. 2016 Jun;34(6):1637-50.

  5. Platero-Luengo A, González-Granero S, Durán R, Díaz-Castro B, Piruat JI, García-Verdugo JM, Pardal R, López-Barneo J. An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell. 2014 Jan 16;156(1-2):291-303.