Martínez Ruiz, Antonio

Redox biomedicine in the response to hypoxia and in pathiophysiology

Redox biomedicine in the response to hypoxia and in pathiophysiology

• Unidad de Investigación, Hospital Santa Cristina, Instituto de Investigación Sanitaria Princesa (IIS-IP)

• Departamento de Bioquímicay Biología Molecular, Facultad de Farmacia, Universidad Complutense de Madrid

• Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)

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Phone number

+ 34 915 574 603

Twitter

@tonnomartinez

Keywords

Redox biomedicine, thiol-based redox signalling, redox proteomics, hypoxia, redox signalling, oxidative stress

Brief description of the research:

Research in the lab is devoted to uncover molecular mechanisms underlying redox responses to acute hypoxia, and their involvement in physiology and pathological scenarios, as well as to develop and apply thiol redox proteomics methods in pathophysiology.

5 selected publications:

Hernansanz-Agustín P, Ramos E, Villa-Piña T, Navarro E, Parada E, Moreno L, Izquierdo-Álvarez A, Oliva T, Cabrera-García JD, Cortés A, Tello D, Acín-Pérez R, Buendia I, Rodríguez Aguilera JC, Navas P, Cogolludo A, Martínez-del-Pozo A, Egea J, López MG, Bogdanova A, Enríquez JA, Martínez-Ruiz A. Mitochondrial Na+ import. controls oxidative phosphorylation and hypoxic redox signalling. bioRxiv 385690; DOI: 10.1101/385690.
Santos AI, Carreira BP, Izquierdo-Álvarez A, Ramos E, Lourenço AS, Santos D, Morte MI, Ribeiro LF, Marreiros A, Sánchez-López N, Marina A, Carvalho CM, Martínez-Ruiz A+, Araújo IM+. S-nitrosylation of Ras mediates nitric oxide dependent post-injury neurogenesis in a seizure model. Antioxid. Redox Signal. (2018) 28, 15-30. + - equal contribution
Hernansanz-Agustín P, Ramos E, Navarro E, Parada E, Sánchez-López N, Peláez-Aguado L, Cabrera-García JD, Tello D, Buendia I, Marina A, Egea J, López MG, Bogdanova A, Martínez-Ruiz A. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia. Redox Biol. (2017) 12, 1040-1051.
Hernansanz-Agustín P, Izquierdo-Álvarez A, Sánchez-Gómez FJ, Ramos E, Villa-Piña T, Lamas S, Bogdanova A, Martínez-Ruiz A. Acute hypoxia produces a superoxide burst in cells Free Radic. Biol. Med. (2014) 71, 146-156.
Izquierdo-Álvarez, A., Ramos, E., Villanueva, J., Hernansanz-Agustín, P., Fernández-Rodríguez, R., Tello, D., Carrascal, M., Martínez-Ruiz, A. Differential redox proteomics allows identification of proteins reversibly oxidized in cysteines in endothelial cells during acute response to hypoxia. J. Proteomics (2012) 75, 5449–5462.