Lucio de, Francisco Javier


Lucio de, Francisco Javier
Lucio de, Francisco Javier

University of Alcalá Dept. Biología de Sistemas

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HIF, prostaglandin E2, prostate cancer, proximal tubular cells, hypoxia inducible factor-1α, retinoic acid receptor beta
Brief description of the research:

We work in human renal proximal tubular HK-2 cells (PTC) and in prostate epithelial cancer cells (non-cancerous and cancerous cell lines). In PTC, we analyse the role of intracellular prostaglandin E2 (iPGE2) in the damage and repair of the proximal renal tubule, with the aim of developing new therapeutic intervention routes based on the modulation of iPGE levels or the activation of intracellular PGE receptors (iEP). In prostate cells, we analyze the role of iPGE2 in the exacerbation of neoplasm-related phenotypes. In both cases, we pay particular attention to the regulation of HIF-1α by iPGE2 and to the role of HIF-1α as a mediator of the effects of iPGE2.

5 selected publications:
  1. Madrigal-Martínez A, Fernández-Martínez AB, Lucio Cazaña FJ. Intracrine prostaglandin E2 pro-tumoral actions in prostate epithelial cells originate from non-canonical pathways.J Cell Physiol 2018; 233:3590-3602

  2. Fernandez-Martínez AB, Benito Martínez S, Lucio-Cazaña FJ Intracellular prostaglandin E2 mediates cisplatin-induced proximal tubular cell death. Biochim Biophys Acta (Molecular cell Research) 2016; 1863:293-302

  3. Martínez AB, Lucio-Cazaña FJ Transactivation of EGFR by prostaglandin E2 receptors: a nuclear story? Cell Mol Life Sci 2015; 72:2187-2198

  4. Fernández-Martínez AB, Arenas-Jimenez MI, Lucio-Cazaña FJ Retinoic acid increases hypoxia-inducible factor-1 through intracrine prostaglandin E2 signalling in human renal proximal tubular cells HK-2 Biochem Biophys Acta [Molecular and Cell Biology of Lipids] 2012; 1821:672-683.

  5. Fernández-Martínez AB, Arenas-Jiménez MI, Moreno-Manzano V, Lucio-Cazaña FJ Intracrine prostaglandin E2 signalling regulates hypoxia-inducible factor-1α expression through retinoic acid receptor-ß Biochem Cell Biol. 2014; 44:2185-2193