Lucio de, Francisco Javier

We work in human renal proximal tubular HK-2 cells (PTC) and in prostate epithelial cancer cells (non-cancerous and cancerous cell lines). In PTC, we analyse the role of intracellular prostaglandin E2 (iPGE2) in the damage and repair of the proximal renal tubule, with the aim of developing new therapeutic intervention routes based on the modulation of iPGE levels or the activation of intracellular PGE receptors (iEP). In prostate cells, we analyze the role of iPGE2 in the exacerbation of neoplasm-related phenotypes. In both cases, we pay particular attention to the regulation of HIF-1α by iPGE2 and to the role of HIF-1α as a mediator of the effects of iPGE2.