López-Barneo, José

Cell Neurobiology and Biophysics

López-Barneo, José

Cell Neurobiology and Biophysics

Instituto de Biomedicina de Sevilla (IBiS)

Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla

Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013-Sevilla

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Phone number

+34 955 923 007

Keywords

oxygen sensing, hypoxia, ion channels, mitochondria, glucose sensing, neurodegeneration

Brief description of the research:

We work on the basic mechanisms underlying oxygen sensing by cells. We pay special attention to unravel the molecular mechanisms of acute oxygen sensing by specialized chemoreceptor cells in the carotid body, arterial smooth muscle and other locations. In addition, we study the role of oxygen, mitochondria, and metabolism on neurogenesis and the protective action of neurotrophic factors in neuronal pathways.

5 selected publications:

Fernández-Agüera MC, Gao L, González-Rodríguez P, Pintado CO, Arias-Mayenco I, García-Flores P, García-Pergañeda A, Pascual A, Ortega-Sáenz P, López-Barneo J. Oxygen sensing by arterial chemoreceptors depends on mitochondrial complex I signaling. Cell Metabolism 2015; 22: 825-837.
Pascual A, Hidalgo-Figueroa M, Piruat JI, Pintado CO, Gómez-Díaz R, López-Barneo J. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nature Neuroscience, 2008; 11:755-761.
Pardal R, Ortega-Sáenz P, Duran R, López-Barneo J. Glia-like stem cells sustain physiologic neurogenesis in the adult carotid body. Cell 2007;131:364-377.
Ureña J, Fernández-Chacón R, Benot A, Alvarez de Toledo G, López-Barneo J. Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells. Proceedings of the National Academy of Sciences (USA) 1994; 91:10208-10211.
López-Barneo J, López-López J, Ureña J, González, C. Chemotransduction in the carotid body. potassium current modulated by pO2 in type I chemoreceptor cells.Science 1988; 241: 580-582.