The research group leaded by Dr. Águeda González Rodríguez involves basic and clinical researchers who actively collaborate to develop a high-level translational research focused on the study of metabolic syndrome and liver diseases. The core research line of the group is based on the identification and characterization of new molecular targets involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), with special emphasis on the study of the mechanisms responsible for the progression of liver disease from the initial stage of simple steatosis until the appearance of steatohepatitis and fibrosis. Regarding hypoxia, one of the research lines of the laboratory is to identify new molecular targets involved in the liver damage induced by intermittent hypoxia, which could be useful as direct biomarkers for a non-invasive diagnosis of NAFLD. Other research line is focused on the study of the association between chronic respiratory diseases and the appearance of cardiovascular and metabolic disorders, determining possible factors (degree of systemic inflammation and grade of hypoxia, among others) involved for this link.
González-Rodríguez A, Más-Gutierrez JA, Mirasierra M, Lee YJ, Ko HJ, Kim JK, Romanos E, Carrascosa JM, Ros M, Vallejo M, Rondinone CM, Valverde AM Essential role of protein tyrosine phosphatase 1b in the development of age-related sencescence, inflammation and insulin resistance Aging Cell 11(2):284-96 (2012)
González-Rodríguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J, Lo Iacono O, Corazzari M, Fimia GM, Piacentini M, Muntané J, Boscá L, García-Monzón C, Martín-Sanz P, Valverde AM. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD Cell Death Dis. 5:e1179 (2014)
González-Rodríguez Á, Santamaría B, Mas-Gutierrez JA, Rada P, Fernández-Millán E, Pardo V, Álvarez C, Cuadrado A, Ros M, Serrano M, Valverde ÁM. (*corresponding authors) Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner Mol Nutr Food Res. 59(8):1431-42 (2015)
Villar-Lorenzo A, Ardiles AE, Arroba AI, Hernández-Jiménez E, Pardo V, López-Collazo E, Jiménez IA, Bazzocchi IL, González-Rodríguez Á, Valverde ÁM. (*corresponding authors) Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages Toxicol Appl Pharmacol. 313:57-67 (2016)
González-Rodríguez Á, Valdecantos MP, Rada P, Addante A, Barahona I, Rey E, Pardo V, Ruiz L, Laiglesia LM, Moreno-Aliaga MJ, García-Monzón C, Sánchez A, Valverde ÁM. (*corresponding authors) Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis Mol Metab. 7:132-146 (2018)