The core research line of the group is based on the study of the mechanisms that trigger neuroinflammation at the CNS level, in their control to identify new targets to offer neuroprotection, and in the search for prognostic biomarkers related to inflammation and oxidative stress, with emphasis on pathologies such as stroke and traumatic brain injury. Specifically, our group focuses on the study of the mechanisms that control the activation of the innate immune system (NLRP3 inflammasome) and its application to the search of new therapeutic targets and of new prognostic/diagnostic biomarkers in stroke, traumatic brain injury and in neurodegenerative diseases. Another research line is focused on the study of how hypoxia affects Blood-Brain Barrier stability.
Casas AI, Geuss E, Kleikers PWM, Mencl S, Herrmann AM, Buendia I, Egea J, Meuth SG, Lopez MG, Kleinschnitz C, Schmidt HHHW. 2017. NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proc Natl Acad Sci U S A. 114; 12315-12320.
Bautista-Aguilera ÓM, Hagenow S, Palomino-Antolin A, Farré-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janočková J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martínez A, López-Muñoz F, Chioua M, Egea J, Ramsay RR, Marco-Contelles J, Stark H. 2017. Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases. Angew Chem Int Ed Engl. 56; 12765-12769.
Ramos E, Patiño P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, de Los Rios C, Romero A, Egea J. 2017. Ischemic brain injury: New insights on the protective role of melatonin. Free Radic Biol Med. 104; 32-53.
Egea J, Buendia I, Parada E, Navarro E, Rada P, Cuadrado A, López MG, García AG, León R. 2015. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. Br J Pharmacol. 172: 1807-21.
Parada E, Buendia I, León R, Negredo P, Romero A, Cuadrado A, López MG, Egea J. 2014. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. Journal of Pineal Research. 56, 204-212.