Cogolludo, Ángel

Fisiopatlogía Vascular Pulmonar

Cogolludo, Ángel
Cogolludo, Ángel
Fisiopatlogía Vascular Pulmonar

Universidad Complutense de Madrid (UCM)

Department of Pharmacology and Toxicology, School of Medicine,
University Complutense of Madrid, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Ciber Enfermedades Respiratorias (CIBERES).

Universidad Complutense de Madrid (UCM)
Pza. Ramón y Cajal, s/n
Ciudad Universitaria

Phone number
Pulmonary hypertension, hypoxia, arteries, potassium channels, ceramide
Brief description of the research:

Our group has more than 20 years of experience in the study of the physiological and pathological mechanisms involved in the regulation of vascular tone. One of our lines of research has focused on characterizing the effects of hypoxia (both acute and chronic) in several vascular beds. Specifically, we have identified the role of ceramide production (from neutral sphingomyelinase) and reactive oxygen species in hypoxic pulmonary vasoconstriction (HPV); a physiological mechanism that allows blood flow to the best ventilated areas of the lung, thereby improving ventilation-perfusion coupling. Another line of research in our group involves the study of vascular potassium channels and their regulation by physiological and pathological factors. Finally, our interest has also focused on identifying cellular and molecular mechanisms involved in the development of lung diseases, especially pulmonary hypertension and acute respiratory distress syndrome.

5 selected publications:
  1. Cogolludo A, Moreno L, Bosca L, Tamargo J y Pérez-Vizcaíno F. Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction. Role of PKCζ. Circ Res. 2003; 93: 656-663.

  2. Cogolludo A, Moreno L, Lodi F, Frazziano G, Tamargo J y Pérez-Vizcaíno F. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells. Role of 5-HT2A receptors, caveolin-1 and KV1.5 channel internalization. Circ Res. 2006; 98: 931-938.

  3. Cogolludo A, Moreno L, Frazziano G, Moral-Sanz J, Menéndez C, Castañeda J, Gonzalez C, Villamor E, Perez-Vizcaino F. Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2009; 82: 296-302.

  4. Moreno L, Moral-Sanz J, Morales-Cano D, Barreira B, Moreno E, Ferrarini A, Pandolfi R, Ruperez FJ, Cortijo J, Sanchez-Luna M, Villamor E, Perez-Vizcaino F, Cogolludo A. Ceramide mediates acute oxygen sensing in vascular tissues. Antioxid Redox Signal. 2014; 20(1):1-14.

  5. Pandolfi R, Barreira B, Moreno E, Lara-Acedo V, Morales-Cano D, Martínez-Ramas A, de Olaiz Navarro B, Herrero R, Lorente JA, Cogolludo A, Perez-Vizcaino F, Moreno L. Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction. Thorax. 2017 May;72(5):460-471.