Aragonés, Julian

OXIDISEASE

Aragonés, Julian

OXIDISEASE

Universidad Autónoma de Madrid. Facultad de Medicina

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Phone number

+34 915 574 498

URL

UAM

Keywords

Hypoxia, HIF, metabolism, cancer

Brief description of the research:

Our scientific group is focused on the biological responses executed by the hypoxia-inducible transcription factors (HIFs) to oxygen fluctuations (hypoxia) in different pathological scenarios of enormous biomedical relevance such as solid tumours progression as well as in the adipose tissue expansion (obesity), respiratory pathology and cardiac and peripheral ischemia. A central biological function of HIF factors is to accommodate cellular metabolism to oxygen supply and several studies of the group have explored the role of this HIF-dependent metabolic rewiring in pathophysiology. In this line, our group is particularly interested in the role of HIF signalling in central metabolic players where we identified the role of HIF2-mTORC1 proliferative pathway in cancer progression and lung biology (Elorza et al., 2012 Molecular Cell, Torres-Capelli et al., 2016 Scientific Reports) as well as the role of HIF1a-dependent mitochondrial reprogramming in obesity (Soro et al., 2016 Cell Reports). Our current research continues in this research line about the role of novel HIF-dependent metabolic pathways in cancer biology but also in other pathological settings characterized by hypoxia such as lung disease and tissue ischemia.

5 selected publications:

Ines Soro-Arnaiz, Qilong Oscar Yang Li, Mar Torres Capelli, Florinda Meléndez-Rodríguez, Ainara Elorza, Sónia Veiga, Koen Veys, Daniel Tello, Pablo Hernansanz-Agustín, Jose Maria Moreno-Navarrete,Eduardo Balsa, Eduardo Romanos, Antonio Martínez-Ruiz, Jose Manuel Fernandez-Real, Antonio Zorzano, Katrien De Bock and Julián Aragonés. Role of mitochondrial complex IV in age-dependent obesity. Cell Reports 2016 Sep 13;16(11):2991-3002.
Mar Torres-Capelli, Glenn Marsboom, Qilong Oscar Yang Li, Daniel Tello, Florinda Melendez Rodriguez, Tamara Alonso, Francisco García Rio, Julio Ancochea and Julián Aragonés. Role of HIF2α oxygen sensing pathway in bronchial epithelial club cell proliferation. Sci. Rep. 2016 May 6;6:25357.
Ainara Elorza, Inés Soro-Arnaiz, Florinda Meléndez-Rodriguez, Victoria Rodriguez-Vaello, Glenn Marsboom, Guillermo de Cárcer, Bárbara Acosta-Iborra, Lucas Albacete-Albacete, Angel Ordoñez, Leticia Serrano-Oviedo, Jose Miguel Gimenez-Bachs, Alicia Vara-Vega, Antonio Salinas, Ricardo Sánchez-Prieto, Rafael Martin del Rio, Francisco Sanchez-Madrid, Marcos Malumbres, Manuel O. Landázuri and Julián Aragonés. (2012). HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Molecular Cell 2012, 48(5). 681-691.
Daniel Tello, Eduardo Balsa, Bárbara Acosta-Iborra, Esther Fuertes-Yebra, Ainara Elorza, Ángel Ordoñez, María Corral-Escariz, Antonio Martínez-Ruiz, Julián Aragonés, Susana Cadenas and Manuel Ortiz de Landázuri. Induction of the mitochondrial NDUFAL2 protein by HIF-1α decreases oxygen consumption by inhibiting complex I activity. Cell Metabolism. 2011 14(6). 768-779
Marta Miró Murillo, Ainara Elorza, Inés Soro, Alicia Vara, Silvia Vázquez, Carmen Fernandez-Criado, Manuel O. Landázuri and Julián Aragonés. Acute vhl inactivation induces cardiac HIF-dependent erythropoietin gene expression PLoS ONE 2011, 6(7):e22589. Epub 2011 Jul 21.